Improving the Obtaining Factors of a Chitosan Hydrogel Based Biomaterial

摘要

The paper aims to optimize the experimental conditions of a hydrogel preparation applied on a textile knitting fabric made of 100 % cotton yarns; one used as input variables: i) the volume of chitosan (CS) solution, ii) lasting time of CS sorption on cellulose and the amount of CS, which correlates with the amount of drug that is included and by default the amount released to the skin. In this study hydrocortisone acetate (HCr) was chosen as drug for coetaneous pathologies. The procedure was applied in the following steps: 1) the application of CS-based hydrogel on knitted fabric; 2) the inclusion of HCr and cross-linker (Na2SO4) in the hydrogel mass deposited on knitted fabric. To release the drug, the assembly of textile support + drug + hydrogel was immersed in a perspiration kit at pH = 5.5 and T = 37 degrees C, which mimics the physiological conditions on the skin. The degree of fabric loading with hydrogel was determined; inclusion ability at 20 degrees C and 50 degrees C and then the kinetics of HCr release at 37 degrees C under the action of a perspiration kit, visual SEM micro photograph of morphological components of fiber with hydrogel and elemental analysis (EDAX).