Genistein and its Fatty Acid Esters as New In vitro Antitumor Compounds

摘要

This present study describes the biological activity of genistein and genistein derivatives with ester structure on two tumor cell lines, A431 (skin epidermoid carcinoma) and A375 (human melanoma). Genistein esters were synthesized following the pathway of chemical esterification which involved solvent medium, triethylamine and fatty acid chloride. Esterification of genistein leads to increased hydrophobicity in order to have a better absorption while the compounds cross the membrane barrier.