Influence of Crosslinking Agent - Chain Extender Ratio on the Properties of Hyperbranched Polyurethane Structures used as Dendritic Drug Carrier

摘要

Polyurethanes (PU) are versatile chemical compounds with vastly differing biological and mechanical properties. The slight possibility of converting their properties allow them to be used in many applications, particularly for the biomedical and pharmaceutical fields. In this study, lysine diisocyanate ester (LDI), tris(hydroxymethyl)aminomethane (THAM), 1,4-butanediol (BD) and polyethylene glycol (PEG) were used to obtain hyperbranched PU structures. There were studied the size and stability of the PU structures and the thermal behavior of samples. In vitro assays on cells culture were used to observe the cytotoxic potential of obtained products. The sizes and stability of the obtained PU structures and the absence of any cytotoxic potential recommend their usage as drug delivery system.