Incorporation of Tobramycin Biomimetic in Hydroxyapatite Coating on CoCrMo Alloy and its Antimicrobial Acitivity

摘要

In this study, we have investigated the incorporation of tobramycin into biomimetic HA coatings applied on CoCrMo implants. Tobramycin can prevent growth of Escherichia coli, a gram-negative bacillus frequently responsible for post-surgical infections in orthopaedic surgery and such antimicrobial activity was demonstrated on biomimetic HA coating. Such bioactive HA coatings on metallic implants have been shown to enhance early bone apposition and fixation of prostheses. Our results demonstrated the efficiency of the biomimetic coatings combined with tobramycin, to prevent local post-surgical infections. This study demonstrated an affinity of tobramycin for HA surfaces as well.