Brdm2 - an aberrant hypomorphic p63 allele.

摘要

In response to our recent report on the Brdm2 mouse model for p63 function, Mikkola et al. raise concerns on three of our statements: (1) they maintain their initial claim that no functional p63 protein of any kind is synthesized in mice homozygous for the Brdm2 allele; (2) they report the occurrence of spontaneous wild-type allelic reversions in these mice, leading to patches of completely normal epidermis, and propose that these normal reverted skin patches are in fact the multilayered epithelia we described; and (3) they insist that the Brdm2 allele is phenotypically indistinguishable from a global p63 knockout.