An autobiographic conversation with Roger D Kornberg on his work on transcription regulation.

摘要

My adult scientific career began with graduate study in chemical physics with Harden McConnell at Stanford. 1 had the idea of elucidating the mechanism of ion transport across biological membranes by nuclear resonance. I thought ion transport must involve rotation of the transport protein in the membrane. Struggling to prove this wrong idea, it occurred to me to study the rotation in the membrane of a lipid molecule, about 1000 molecular weight, rather than a protein 50 times larger.