Composite Module Analyst: Tool for Prediction of DNA Transcription Regulation. Testing on Simulated Data

摘要

Functionally related genes involved in the same molecular-genetic, biochemical, or physiological process are often regulated coordinately Such regulation is provided by precisely organized binding of a multiplicity of spe cial proteins- transcription factors to their target sites (cis-elements) in regulatory regions of genes. Cis-element combinations provide a structural basis for the generation of unique patterns of gene expression. Here we present new method based on genetic algorithm for prediction of class-specific composite modules in promoters of functionally related or coexpressed genes and it's testing on simulated data.