Broad-spectrum caspase inhibitors: from myth to reality?

摘要

The Nomenclature Committee on Cell Death has recently warned the scientific community when using terms such as 'caspase-dependent versus caspase-independent cell death' to classify apoptotic versus nonapoptotic cell death.1 We strongly agree with this recommendation and we want to add a word of caution concerning the use of broad-spectrum caspase inhibitors in elucidating apoptotic pathways.