Use of 'on line [C-11]methylation' in the synthesis of L-[O-C-11-methyl]tyrosine, a promising radiotracer for positron emission tomography

摘要

A labeled tyrosine analog, viz., L- [O-C-11-methylityrosine ([C-11]MT), was obtained by a reaction of [(11)-C]-methyl iodide with a tyrosine salt in DMSO in the presence of tetrabutylammonium hydroxide on the Sep-Pak tC18 cartridge surface. The efficiency of the "on line O-[C-11] methylation" was 55%.