Ser58 of mouse p53 is the homologue of human Ser46 and is phosphorylated by HIPK2 in apoptosis.

摘要

The tumor suppressor p53 is known to function in the prevention of genetic instability and in the activation of apoptosis. To mediate these functions, the constitutively expressed latent form of p53 is activated by a series of post-translational modifications that occur at the N- and C-terminal regions. Among the post-translational modifications, phos-phorylation of human p53 (hp53) at Ser46 was identified as a specific modification involved in apoptotic response. Compared to other N-terminal phosphorylation sites, nearly 100% conserved in different species, the region encompassing Ser46 has low level of amino-acid (aa) identity questioning the existence of a Ser46 homologue site in mice.