A simple, efficient, and practical method for the phenylselenylation of imidazo[1,2-a]pyridines via electrophilic substitution employing readily available phenylselenium bromide has been developed in aqueous media at roomtemperature. A library of 3-phenylselenylimidazo[1,2-a]pyridines has been synthesized employing this methodology with high yields. The present protocol is also applicable for the phenylselenylation of imidazo[2,1-b]thiazole and benzo[d]imidazo[2,1-b]-thiazole.
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