Treating experimental arthritis with the innate immune inhibitor interleukin-37 reduces joint and systemic inflammation

Cavalli Giulio; Koenders Marije; Kalabokis Vassili; Kim Jihye; Tan Aik Choon; Garlanda Cecilia; Mantovani Alberto; Dagna Lorenzo; Joosten Leo A. B.; Dinarello Charles A.

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Treating experimental arthritis with the innate immune inhibitor interleukin-37 reduces joint and systemic inflammation

机译：用先天性免疫抑制剂白细胞介素37治疗实验性关节炎可减轻关节和全身性炎症

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Objectives. The IL-1 family member IL-37 was recently characterized as a fundamental inhibitor of innate inflammation. We investigated the effects of recombinant IL-37 in joint inflammation and joint pathology in a mouse model of arthritis. In addition, we explored the potential for therapeutic use in human joint inflammation.

机译：目标。 IL-1家族成员IL-37最近被表征为先天性炎症的基本抑制剂。我们调查了关节炎小鼠模型中关节炎症和关节病理中重组IL-37的影响。另外，我们探索了在人类关节发炎中治疗用途的潜力。

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《Rheumatology》 |2016年第12期|共10页
作者
Cavalli Giulio; Koenders Marije; Kalabokis Vassili; Kim Jihye; Tan Aik Choon; Garlanda Cecilia; Mantovani Alberto; Dagna Lorenzo; Joosten Leo A. B.; Dinarello Charles A.;
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正文语种 eng
中图分类免疫性疾病;
关键词
cytokine; IL-1 beta; TNF-alpha; neutrophils; rheumatoid arthritis; chemokines; immunotherapy;

机译：细胞因子;IL-1β;TNF-α;中性粒细胞;类风湿关节炎;趋化因子;免疫治疗;

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1. Treating experimental arthritis with the innate immune inhibitor interleukin-37 reduces joint and systemic inflammation [J] . GiulioCavalli, MarijeKoenders, VassiliKalabokis, Rheumatology . 2017,第12期

机译：用先天免疫抑制剂中白细胞介素-37治疗实验性关节炎减少了关节和全身炎症
2. Expression of CD44 and L-selectin in the innate immune system is required for severe joint inflammation in the proteoglycan-induced murine model of rheumatoid arthritis. [J] . Sarraj B, Ludanyi K, Glant TT, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2006,第3期

机译：在蛋白聚糖诱导的类风湿关节炎小鼠模型中，严重的关节炎症需要先天免疫系统中CD44和L-选择素的表达。
3. Expression of CD44 and L-Selectin in the Innate Immune System Is Required for Severe Joint Inflammation in the Proteoglycan-Induced Murine Model of Rheumatoid Arthritis [J] . Bara Sarraj, Katalin Ludányi, Tibor T. Glant, The journal of immunology . 2006,第3期

机译：蛋白聚糖诱导的类风湿关节炎小鼠模型中的严重关节炎症需要先天免疫系统中CD44和L选择素的表达。
4. Liposomal alendronate inhibits systemic innate immunity and reduces size and number of endometriosis implants in rats [C] . E. Haber, N. Koroukhov, G. Golomb, Controlled Release Society Annual Meeting and Exposition . 2007

机译：脂质体阿仑膦酸盐抑制系统性先天免疫，并减少大鼠子宫内膜异位植入物的大小和数量
5. Systemic immune responses to intestinal-derived lipopolysaccharide (LPS) during subacute ruminal acidosis (SARA) and their possible role in innate immunity [D] . Kroeker, Angela. 2012

机译：亚急性瘤胃酸中毒（SARA）期间对肠源性脂多糖（LPS）的全身免疫反应及其在先天免疫中的可能作用
6. Treating experimental arthritis with the innate immune inhibitor interleukin-37 reduces joint and systemic inflammation [O] . Giulio Cavalli, Marije Koenders, Vassili Kalabokis, -1

机译：用先天性免疫抑制剂白细胞介素37治疗实验性关节炎可减轻关节和全身性炎症
7. Treating experimental arthritis with the innate immune inhibitor interleukin-37 reduces joint and systemic inflammation [O] . Giulio Cavalli, Marije Koenders, Vassili Kalabokis, 2016

机译：用先天免疫抑制剂中白细胞介素-37治疗实验性关节炎减少了关节和全身炎症

Treating experimental arthritis with the innate immune inhibitor interleukin-37 reduces joint and systemic inflammation

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