Water-soluble platinum(II) complexes of reduced amino acid Schiff bases: Synthesis, characterization, and antitumor activity

摘要

A series of water-soluble platinum(II) complexes of reduced amino acid Schiff bases were synthesized as potential anticancer agents and characterized by ~1H NMR, EA, MS, IR, and molar conductivity. These compounds were tested for their DNA interaction with salmon sperm DNA, and their in vitro anticancer activities have been validated against HL-60, KB, BGC-823, and Bel-7402 cell lines by the MTT assay. The cytotoxicity of one complex (5g) is better than that of cisplatin against BGC-823 and HL-60 cell lines, and show close cytotoxic effect against Bel-7402 cell line.