Synthesis, characterization and cytotoxicity of platinum(II) complexes containing reduced amino acid ester Schiff bases

摘要

Nine platinum(II) complexes containing reduced amino acid ester Schiff bases were synthesized and characterized using spectroscopy (H-1 NMR, C-13 NMR, infrared), elemental analysis and molar conductivity. The interaction of these complexes with salmon sperm DNA was investigated by means of ultraviolet and circular dichroism spectroscopies. The potential antitumor activity of all compounds was tested in vitro on HeLa and A549 tumor cell lines. Almost all the complexes exhibited better cytotoxic activity than cisplatin against these cell lines.