Comparative analysis of transcriptomics based hypoxia signatures in head- and neck squamous cell carcinoma

摘要

Background and purpose: Hypoxia renders tumors resistant to radiotherapy. However, the paucity of sensitive and reliable methods for detection of tumor hypoxia limits the translation of novel therapy strategies targeting this well-known resistance factor. We sought to investigate the ability of three previously discovered transcriptomics based hypoxia signatures to identify hypoxic tumors and consequently discriminate between patients with poor-vs. good prognosis.