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首页> 外文期刊>Regulatory Toxicology and Pharmacology: RTP >Sucralose revisited: Rebuttal of two papers about Splenda safety
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Sucralose revisited: Rebuttal of two papers about Splenda safety

机译:再三氯蔗糖:反驳关于Splenda安全性的两篇论文

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Two critiques were published in Regulatory Toxicology and Pharmacology (Grotz and Munro, 2009; Brusick et al., 2009) subsequent to our publication (Abou-Donia et al., 2008). In our controlled study, Splenda (comprised of the organochlorine sweetener, sucralose and the fillers maltodextrin and glucose) was administered at: 1.1, 3.3, 5.5 and 11 mg/kg/day sucralose; control: 0 mg/kg/day in water, over 12 weeks. These dosages were chosen based on doses approved by the FDA (US FDA, 1998) and the European Union (EU, 2004). Half of the animals were sacrificed at 12 weeks and half after 12 weeks of recovery without Splenda.
机译:在我们发表(Abou-Donia等,2008)之后,在《管理毒理学和药理学》(Grotz和Munro,2009; Brusick等,2009)中发表了两种批评。在我们的对照研究中,Splenda(由有机氯甜味剂,三氯蔗糖以及麦芽糊精和葡萄糖填充剂组成)的施用量为:三氯蔗糖1.1、3.3、5.5和11 mg / kg;对照:在水中0毫克/千克/天,持续12周。这些剂量是根据FDA(美国FDA,1998)和欧盟(EU,2004)批准的剂量选择的。在没有Splenda的情况下,在恢复的第12周处死动物的一半,在恢复12周后处死一半的动物。

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