Endocannabinoids and non-endocannabinoid fatty acid amides in cirrhosis

摘要

Cirrhosis and portal hypertension are associated with haemodynamic derangement, consisting of peripheral and splanchnic vasodilatation, and hyperdynamic circulation. Various gut-derived or locally produced humoral factors such as nitric oxide, endotoxin and glucagon have been implicated as important mediators for the development of vasodilatation and hyperdynamic circulation in cirrhosis (1).