Super-enhancer RNA m6A promotes local chromatin accessibility and oncogene transcription in pancreatic ductal adenocarcinoma

RuiLi; HongzheZhao; XudongHuangJialiangZhangRuihongBaiLishaZhuangShujuanWenShaojiaWuQuanboZhouMeiLiLingxingZengShaopingZhangShuangDengJiachunSuZhixiangZuoRufuChenDongxinLinJianZheng

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Super-enhancer RNA m6A promotes local chromatin accessibility and oncogene transcription in pancreatic ductal adenocarcinoma

机译：超级增强子 RNA m6A 促进胰腺导管腺癌的局部染色质可及性和癌基因转录

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In pancreatic duct adenocarcinoma, super-enhancer RNAs (seRNAs) have higher N6-methyladenosine (m6A) levels than in adjacent normal tissue due to upregulation of the METTL3 cofactor CFL1. Aberrant m6A seRNAs promote oncogene expression via the YTHDC2–MLL1 complex.

机译：在胰管腺癌中，由于 METTL3 辅因子 CFL1 的上调，超级增强子 RNA （seRNA）的 N6-甲基腺苷（m6A）水平高于邻近正常组织。异常的 m6A seRNA 通过 YTHDC2–MLL1 复合物促进癌基因表达。

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《Nature Genetics》 |2023年第12期|2224-2234|共11页
作者
RuiLi; HongzheZhao; XudongHuangJialiangZhangRuihongBaiLishaZhuangShujuanWenShaojiaWuQuanboZhouMeiLiLingxingZengShaopingZhangShuangDengJiachunSuZhixiangZuoRufuChenDongxinLinJianZheng;
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Guangdong Provincial People’s Hospital & Guangdong Academy of Medical Sciences;

Guangdong Provincial People’s Hospital & Guangdong Academy of Medical SciencesState Key Laboratory;

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正文语种英语
中图分类医学遗传学;自然研究、自然历史;遗传学;
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1. Chromatin accessibility uncovers KRAS-driven FOSL2 promoting pancreatic ductal adenocarcinoma progression through up-regulation of CCL28 [J] . Zhang Shujun, Li Peilong, Li JuanGao JieQi QiuchenDong GuoyingLiu XiaoyanJiao QinlianWang YunshanDu LutaoZhan HanxiangXu ShuoWang Chuanxin The British journal of cancer . 2023,第3期

机译：染色质可及性揭示了 KRAS 驱动的 FOSL2 通过上调 CCL28 促进胰腺导管腺癌进展
2. RNA m6A regulates transcription via DNA demethylation and chromatin accessibility [J] . ShuangDeng, JialiangZhang, JiachunSuZhixiangZuoLingxingZengKaijingLiuYanfenZhengXudongHuangRuihongBaiLishaZhuangYingYeMeiLiLingPanJungeDengGuandiWuRuiLiShaopingZhangChenWuDongxinLinJianjunChenJianZheng Nature Genetics . 2022,第9期

机译：RNA m6A 通过 DNA 去甲基化和染色质可及性调节转录
3. Galectin-1 secreted by activated stellate cells in pancreatic ductal adenocarcinoma stroma promotes proliferation and invasion of pancreatic cancer cells: an in vitro study on the microenvironment of pancreatic ductal adenocarcinoma. [J] . Xue X, Lu Z, Tang D, Pancreas . 2011,第6期

机译：胰腺导管腺癌基质中星状细胞活化分泌的Galectin-1促进胰腺癌细胞的增殖和侵袭：胰导管腺癌微环境的体外研究。
4. Integrative network analysis identified master regulatory long non-coding RNAs underlying the squamous subtype of pancreatic ductal adenocarcinoma [C] . Lina ZHU, Xin WANG IEEE International Conference on Bioinformatics and Biomedicine . 2020

机译：综合网络分析鉴定胰腺导管腺癌鳞状亚型鳞状亚底层的校长监管长非编码RNA
5. Characterization and Application of Highly Specific 2'-F RNA Aptamers Targeting a Potentially Novel Pancreatic Ductal Adenocarcinoma (PDAC) Biomarker(s). [D] . Claypool, Sarah Eileen. 2015

机译：靶向潜在的新型胰导管腺癌（PDAC）生物标记物的高特异性2'-F RNA适体的表征和应用。
6. Glycemic Variability Promotes Both Local Invasion and Metastatic Colonization by Pancreatic Ductal Adenocarcinoma [O] . Ziying Jian, Tao Cheng, Zhiheng Zhang, 2018

机译：血糖变异性促进胰腺导管腺癌的局部侵袭和转移定植。
7. CircNEIL3 regulatory loop promotes pancreatic ductal adenocarcinoma progression via miRNA sponging and A-to-I RNA-editing [O] . Peng Shen, Taoyue Yang, Qun Chen, 2021

机译：Circneil3调节回路通过MiRNA海绵和A-to-I RNA编辑促进胰腺导管腺癌进展

Super-enhancer RNA m6A promotes local chromatin accessibility and oncogene transcription in pancreatic ductal adenocarcinoma

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