Protective effects of PPARγ agonist in glomerulosclerosis rats induced by adriamycin

摘要

Peroxisome proliferator-activated receptor gamma (PPARγ) agonists have beneficial effects on renal damage associated with different pathologies. The model of glomeruli lesion induced by puromycin aminonucleoside (PAN) is a classical model of acute nephrotic syndrome. Zuo et al.1 performed an interesting investigation on the association of PPARγ agonist (pioglitazone) treatment with minimal-change disease (MCD) or early-stage focal segmental glomerulosclerosis in rats induced by a single dose of PAN. They observed that the PPARγ expression in MCD model group was weakened and found that PPARγ agonists decreased proteinuria in acute nephrotic syndrome rats. They drew a conclusion that PPARγ agonist treatment was a therapeutic strategy for glomeruli lesion. Read More: http://informahealthcare.com/doi/full/10.3109/0886022X.2012.691066