Normalization of kidney dysfunction in normotensive, normo-albuminuric type 2 diabetes

摘要

It has been a general consensus that a majority of diabetic nephropathic patients associated with stages 1, 2 (creatinine clearance 90–119, 60–89?mL/min/1.73?m2, respectively) have been recognized prior to the onset of microalbuminuria. Such early impaired renal function usually correlates with (i) the altered renal hemodynamics characterized by reductions in renal plasma flow and peritubular capillary flow,1 an abnormally elevated renal arteriolar resistance and a glomerular hyperfiltration2,3 and (ii) an abnormally elevated value of fractional excretion of magnesium (FE Mg) ? a biomarker, which directly reflects the presence of tubulointerstitial fibrosis in this early stage of diabetic nephropathy, since FE Mg has previously been demonstrated to correlate directly with the magnitude of tubulointerstitial Read More: http://informahealthcare.com/doi/full/10.3109/0886022X.2013.810541