Isotope-labeled differential profiling of metabolites using N-benzoyloxysuccinimide derivatization coupled to liquid chromatography/high-resolution tandem mass spectrometry

摘要

RATIONALE: An isotopic labeling strategy based on derivatizing amine-containing metabolites has been developed using light (C-12(6)) and heavy (C-13(6)) N-benzoyloxysuccinimide reagents for semi-targeted metabolomic applications.