Successful treatment of refractory subcutaneous panniculitis-like T-cell lymphoma with allogeneic peripheral blood stem cell transplantation from HLA-mismatched sibling donor

摘要

Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is an uncommon type of peripheral T-cell lymphoma (PTCL) usually presenting with erythe-matous, subcutaneous nodules and fever. It is considered as a cytotoxic T-cell neoplasm with cyo-toxic granules and can be cytochemically identified using granzyme B, perform or TIA-1. Some cases of SPTCL might be indolent for months or years, but SPTL frequently has an aggressive course, and is often complicated by fatal hemophagocytic syndrome (HPS).Among the cases of SPTCL, resistance to anthracyclin-based therapy generally means a poor prognosis. The use of high-dose therapy (HDT) with autologous stem cell transplantation (SCT) in patients with SPTCL who are refractory to anthra-cyclins has yielded good results. However, a cure can only be expected if the disease is at least sensitive to HDT. Allogeneic SCT, however, might yield a cure even in chemo-refractory lymphoma patients via a graft-vs.-lymphoma (GVL) effect. We report a case of successful use of an allogeneic peripheral blood stem cell transplantation (allo-PBSCT) from an HLA-mismatched sibling donor in a patient with SPTCL who was refractory to conventional chemotherapy.