T-cell/histiocyte-rich B-cell lymphoma and the paradox of the host immune response.

摘要

T-cell/histiocyte rich (T/HRBCL) is an uncommon morphologic variant of diffuse large B-cell lymphoma (DLBCL) characterized by distinct clinicopathologic features. Since it's original description, multiple small series have shed light on the unique clinical features of this entity, including a younger age at presentation, male predominance, and a higher frequency of involving the bone marrow, liver, and spleen compared with DLBCL as a whole . Histologically, this disease stands apart from most lymphomas, and cancers in general, in that the malignant B-cells represent a minor fraction (less than 10%) of the overall tumor cellularity, with the majority of cells being the infiltrating polyclonal T-cells and histiocytes for which the disease entity is named.