Bio-compatible eutectic mixture for multi-component synthesis: A valuable acidic catalyst for synthesis of novel 2,3-dihydroquinazolin-4(1H)-one derivatives

摘要

Novel derivatives of quinazolin-4(1H)-one derivatives were effectively synthesized via one-pot multi-component reaction of isatoic anhydride, aldehyde and aromatic amines using acidic catalyst in methanol. The catalyst, being a deep eutectic mixture of choline chloride and malonic acid, gave better results than several reported catalysts. Moreover, such eutectic mixtures are cost-effective, recyclable, non-toxic and bio-degradable. The methodology was successfully used for incorporating significant phenyl and heterocyclic substitutions at 2,3-positions of quinazolinone core. In addition, studies related to catalyst screening, substrate variation, recyclability and plausible mechanism of reaction are also described.