Immune responses to JC virus in patients with multiple sclerosis treated with natalizumab: a cross-sectional and longitudinal study

Jilek Samantha; Jaquiery Emilie; Hirsch Hans H.; Lysandropoulos Andreas; Canales Mathieu; Guignard Laurence; Schluep Myriam; Pantaleo Giuseppe; Du Pasquier Renaud A.

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Immune responses to JC virus in patients with multiple sclerosis treated with natalizumab: a cross-sectional and longitudinal study

机译：那他珠单抗治疗的多发性硬化症患者对JC病毒的免疫反应：横断面和纵向研究

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Background Natalizumab is used to prevent relapses and progression of disability in patients with multiple sclerosis but has been associated with progressive multifocal leukoencephalopathy (PML). We aimed to better understand the associations between JC virus, which causes PML, and natalizumab treatment.

机译：背景纳他珠单抗用于预防多发性硬化症患者的复发和残疾发展，但已与进行性多灶性白质脑病（PML）相关。我们旨在更好地了解导致PML的JC病毒与那他珠单抗治疗之间的关联。

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《Lancet Neurology 》 |2010年第3期| 共9页
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Jilek Samantha; Jaquiery Emilie; Hirsch Hans H.; Lysandropoulos Andreas; Canales Mathieu; Guignard Laurence; Schluep Myriam; Pantaleo Giuseppe; Du Pasquier Renaud A.;
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中图分类神经病学与精神病学 ;
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1. Immune responses to JC virus in patients with multiple sclerosis treated with natalizumab: a cross-sectional and longitudinal study [J] . Jilek Samantha, Jaquiery Emilie, Hirsch Hans H., Lancet Neurology . 2010 ,第3期

机译：那他珠单抗治疗的多发性硬化症患者对JC病毒的免疫反应：横断面和纵向研究
2. No evidence of JC virus reactivation in natalizumab treated multiple sclerosis patients: an 18 month follow-up study. [J] . Rinaldi L, Rinaldi F, Perini P, Journal of Neurology, Neurosurgery and Psychiatry . 2010 ,第12期

机译：在那他珠单抗治疗的多发性硬化症患者中没有JC病毒激活的证据：一项为期18个月的随访研究。
3. Association of Progressive Multifocal Leukoencephalopathy Lesion Volume With JC Virus Polymerase Chain Reaction Results in Cerebrospinal Fluid of Natalizumab-Treated Patients With Multiple Sclerosis [J] . Martijn T.?Wijburg, Iris?Kleerekooper, Birgit I.?Lissenberg-Witte, JAMA neurology . 2018 ,第7期

机译：渐进式多焦白血病病变性能与JC病毒聚合酶链反应导致纳莱普治疗的多发性硬化症患者的脑脊液
4. Human Endogenous Retrovirus Expression Is Specifically Associated with Multiple Sclerosis: Immune Responses to HERVs in MS [C] . T. Christensen, T. Brudek, P.D. S rensen, European Congress of Virology . 2004

机译：人类内源性逆转录病毒表达与多发性硬化症有关：对MS中对疱疹的免疫应答
5. Persistence of HIV-1 despite highly active antiretroviral therapy (HAART) and immune responses: Evidence for a novel viral reservoir in patients on HAART and characterization of HIV-1 virus and immune responses in elite suppressors. [D] . Bailey, Justin R. 2007

机译：尽管有高活性的抗逆转录病毒疗法（HAART）和免疫应答，但HIV-1仍持续存在：有证据表明在HAART患者中出现了新型病毒库，并且有关于HIV-1病毒和精英抑制者免疫应答的特征。
6. JC virus detection and JC virus-specific immunity in natalizumab-treated Multiple Sclerosis patients [O] . Roberta Mancuso, Marina Saresella, Ambra Hernis, 2012

机译：那他珠单抗治疗的多发性硬化症患者的JC病毒检测和JC病毒特异性免疫
7. Immune responses to JC virus in patients with multiple sclerosis treated with natalizumab: a cross-sectional and longitudinal study. [O] . Jilek, S., Jaquiéry, E., Hirsch, H.H., 2010

机译：那他珠单抗治疗的多发性硬化症患者对JC病毒的免疫反应：一项横断面和纵向研究。

Immune responses to JC virus in patients with multiple sclerosis treated with natalizumab: a cross-sectional and longitudinal study

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