method of inducing a memory t-cell immune response against at least one antigen in a human patient, use of an immunogenic composition comprising a non-replicating or replication-matched virulent infection virus vector expressing the translation product of a mycobacterial ag85a gene, use of an antigen in the manufacture of a medicament for treating a disease in a patient by inducing a central memory t-cell immune response and vector vaccine

摘要

METHOD OF INDUCTION OF AN IMMUNOLOGICAL RESPONSE OF MEMORY CELL AGAINST AT LEAST AN ANTIGEN IN A HUMAN PATIENT, USE OF AN IMMUNOGENIC COMPOSITION UNDERSTANDING A VECTOR OF VIRULENT INFECTION OF NON-RADIOPRODUCED VIRUS REPLANT INFECTION A GENE OF MYCOBACTERIAL AG85A, USE OF AN ANTIGEN IN MANUFACTURING A MEDICINAL PRODUCT FOR THE TREATMENT OF A DISEASE IN A PATIENT BY INDUCING AN IMMUNOLOGICAL RESPONSE OF VECTOR CENTRAL MEMORY CELL AND VACCINE. It is a method of generating a T-cell immune response in a host, which involves administering a vectorized vaccine comprising a damaged non-replicating or replicating viral vector that expresses the translation product of a gene. 85A of mycobacterial antigen. Vectorized vaccines and their uses are also presented. Also disclosed is a method for inducing a CD8 and CD4 memory T cell response against an antigen using an adenovirus vector expressing an antigen or an immunogenic fragment thereof.