Effects of chronic wine and alcohol intake on glutathione andmalondialdehyde levels in rats

摘要

Plasma, liver and kidney malondialdehyde (MDA) and liver and kidney glutathione levels were determined to evaluate the effect of the chronic intake of wine or alcohol on oxidative metabolism. Wistar rats were treated in separate groups as follows: control (standard diet and water), sweet wine (the same diet plus sweet wine) and a hydroalcoholic solution equivalent to sweet wine (20% ethanol + 130 g/L glucose + fructose) for 6 months. The consumption of alcoholic beverages was free because the rat could always choose between alcoholic beverage and water. In liver, alcohol ingestion resulted in higher MDA levels but this did not occur in kidney or plasma. Moreover, the reduced glutathione/oxidized glutathione ratio was lower in liver after 6 months of wine or alcohol consumption, but in kidney this ratio was only lower in the case of wine. This study shows that the quantity of phenolic compounds in this sweet wine does not counteract alcohol-induced hepatic oxidation caused by chronic and high consumption.