(332c) Chronic Alcohol Effects On the System-Wide Transcriptional Regulatory Network Modules and Dynamics During Rat Liver Regeneration

摘要

Liver regeneration is a complex, yet remarkably coordinated, process characterized by system-wide gene expression changes underlying the response of the liver tissue to acute damage through mechanical, chemical or viral mechanisms. This normal regenerative response is impaired by acute or chronic alcohol exposure. Such an alcohol-mediated disruption of repair mechanisms presumably contributes to the onset of liver damage in alcoholic liver disease. While progress has been made in understanding several aspects of liver regeneration, the system-wide mechanisms by which these are impaired by chronic alcohol exposure remain largely unexplained. This study aims to characterize how chronic ethanol treatment affects the transcriptomic regulatory dynamics in regenerating liver.