Objective: To explore the Influence of chronic alcohol irigestion on redox function in rats with endogenous and external acute lung injury. Methods: The changs of PaO2, W/D value and the level of lutathione (GSH), superoxide dismu-tasc (SOD), malonaldchyde (MDA) in lung and liver constitution of rats with acute lung injury caused by pulmonary and ex -trapulmonary disease were observed. Results: The levels of GSH in lung and liver tissue were statistically decreased, at the same time MDA level Increased In alcohol-Injury groups compared with water-Injury groups, the differences were statlstl -cally significant (P<0.05). The changes of GSH, MDA level were more deteriorated of external acute lung injury than that of endogenous acute lung injury, the differences were statistically significant (P<0.05). Conclusion: Chronic alcohol ingestion can reduce the function of antloxidant defense of lungs and also aggravate the acute lung injury caused by Intrinsic and extrinsic factors.%目的:探讨长期饮酒对内外源性肺损伤时氧化还原功能的影响.方法:采用长期饮酒后内、外源性肺损伤大鼠模型进行动脉血气、肺湿干比(W/D)和肺、肝组织还原性谷胱甘肽(GSH)、超氧化物歧化酶(SOD)、丙二醛(MDA)检测.结果:长期饮酒后内、外源性肺损伤组大鼠肺、肝组织GSH 水平较饮水损伤组明显下降,MDA 水平显著升高,且外源性肺损伤组GSH、MDA 改变较内源性肺损伤明显,差异均有统计学意义(P<0.05).结论:长期饮酒导致肺脏抗氧化功能下降,加重了内、外源因素引起的肺损伤.
展开▼
