Numerical simulation of a new probe for the alternate cooling and heating of a subcutaneous mouse tumor model

摘要

A new probe for the alternate cooling and heating of a subcutaneous tumor was designed based on numerical simulations in this study. In conjunction with a thermal system built in our lab, it facilitates liquid nitrogen cooling and radiofrequency (RF) heating within one probe. Simulations were performed to study the effects of the probe length, probe inner tube diameter, and liquid nitrogen flow pressure on the probe cooling capacity. Three probes were fabricated with optimized parameters. Experimental measurements were made in gelatin to validate the simulated results and to demonstrate the probe efficiency.