PROBLEM TO BE SOLVED: To create a highly accurate numerical model by reducing human labor and time. A method for preparing a simulated sample is a pre-culture liquid medium not used for culturing a sample, a post-culture liquid medium used for culturing a sample, and at least one of saccharides, amino acids, metabolites, and proteins. It is characterized in that a simulated sample is prepared by mixing with an additive containing. Further, the numerical model creation system includes a spectroscopic analyzer that acquires spectrum data of a simulated sample, a reference value measuring device that measures a reference value of the simulated sample, and the spectrum data and the reference value obtained from a plurality of simulated samples. Based on the above, the present invention is characterized by comprising an analyzer for generating a numerical model representing the correlation between the spectrum data and the reference value. [Selection diagram] Fig. 1
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