1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine (ECyd, TAS-106)1: antitumor effect and mechanism of action.

Azuma A; Matsuda A; Sasaki T; Fukushima M

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1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine (ECyd, TAS-106)1: antitumor effect and mechanism of action.

机译：1-（3-C-乙炔基-β-D-核糖-呋喃糖基）胞嘧啶（ECyd，TAS-106）1：抗肿瘤作用和作用机理。

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摘要

The antitumor activity, cellular metabolism and mechanism of action of the antitumor nucleoside analog, 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine (ECyd) are described.

机译：描述了抗肿瘤核苷类似物1-（3-C-乙炔基-β-D-核糖-戊呋喃糖基）胞嘧啶（ECyd）的抗肿瘤活性，细胞代谢和作用机理。

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《Nucleosides, nucleotides and nucleic acids》 |2001年第7期|共11页
作者
Azuma A; Matsuda A; Sasaki T; Fukushima M;
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正文语种 eng
中图分类细胞形态学;
关键词
Antimetabolites; Antineoplastic; Cytidine; 抗代谢药; 抗肿瘤; 胞苷;

机译：Antimetabolites;Antineoplastic;Cytidine;抗代谢药;抗肿瘤;胞苷;

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1. 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine (ECyd, TAS-106)1: antitumor effect and mechanism of action. [J] . Azuma A, Matsuda A, Sasaki T, Nucleosides, nucleotides and nucleic acids . 2001,第4a7期

机译：1-（3-C-乙炔基-β-D-核糖-呋喃糖基）胞嘧啶（ECyd，TAS-106）1：抗肿瘤作用和作用机理。
2. Antitumor activity and pharmacokinetics of TAS-106, 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine. [J] . Shimamoto Y, Fujioka A, Kazuno H, Japanese Journal of Cancer Research . 2001,第3期

机译：TAS-106，1-（3-C-乙炔基-β-D-核糖-戊呋喃糖基）胞嘧啶的抗肿瘤活性和药代动力学。
3. An RNA-directed nucleoside anti-metabolite, 1-(3-C-ethynyl-beta-d-ribo-pentofuranosyl)cytosine (ECyd), elicits antitumor effect via TP53-induced Glycolysis and Apoptosis Regulator (TIGAR) downregulation. [J] . Lui VW, Lau CP, Cheung CS, Biochemical Pharmacology . 2010,第12期

机译：RNA定向的核苷抗代谢物1-（3-C-乙炔基-β-d-核糖-戊呋喃糖基）胞嘧啶（ECyd）通过TP53诱导的糖酵解和细胞凋亡调节剂（TIGAR）下调引起抗肿瘤作用。
4. 1-( β-D-ARABINOFURANOSYL)CYTOSINE (ARA-C) POLYMER CONJUGATES FOR CONTROLLED RELEASE [C] . O. Schiavon, G. Pasut, C. Marzano, International symposium on controlled release of bioactive materials;Consumer diversified products conference . 2001

机译：1-（β-D-阿拉伯氨基呋喃糖基）胞嘧啶（ARA-C）聚合物共轭物用于控制释放
5. Mechanisms of cytosine deamination to uracil and repair of uracil:guanine mispairs to cytosine:guanine. [D] . Sharath, Anusha Nallarajah. 2001

机译：胞嘧啶脱氨基化尿嘧啶的机制和尿嘧啶：鸟嘌呤错配修复的胞嘧啶：鸟嘌呤。
6. 1-((S)-2-hydroxy-2-oxo-142-dioxaphosphorinan-5-yl)methyl cytosine an intracellular prodrug for (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine with improved therapeutic index in vivo. [O] . N Bischofberger, M J Hitchcock, M S Chen, 1994

机译：1-（（（S）-2-hydroxy-2-oxo-142-dioxaphosphorinan-5-yl）methyl cytosine（S）-1-（3-hydroxy-2-phosphonylmethoxypropyl的细胞内前药胞嘧啶具有改善的体内治疗指数。
7. Possible antitumor activity of 1-(3-C-ethynyl-beta-d-ribo-pentofuranosyl)cytosine (ECyd, TAS-106) against an established gemcitabine (dFdCyd)-resistant human pancreatic cancer cell line [O] . Hiromi Kazuno, Kazuki Sakamoto, Akio Fujioka, 2005

机译：1-（3- c-乙炔基-D-Tirbo-戊脲胶囊基）胞嘧啶（ECYD，TAS-106）的可能抗肿瘤活性对已建立的吉西他滨（DFDCYD） - 培养的人胰腺癌细胞系
8. Cytoprotection of Human Endothelial Cells Against Oxidative Stress by 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole (CDDO-Im): Application of Systems Biology to Understand the Mechanism of Action. [R] . Wang, X., Bynum, J. A., Stavchansky, S., 2014

机译：1- [2-氰基-3,12-二氧杂环戊烷-1,9（11） - 二烯-28-基]咪唑（CDDO-Im）对人内皮细胞对氧化应激的细胞保护作用：应用系统生物学理解机理行动

1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine (ECyd, TAS-106)1: antitumor effect and mechanism of action.

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