Synthesis and biological activity of 5',9-anhydro-3-purine-isonucleosides as potential anti-hepatitis C virus agents.

Chun BK; Wang P; Hassan A; Du J; Tharnish PM; Murakami E; Stuyver L; Otto MJ; Schinazi RF; Watanabe KA

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Synthesis and biological activity of 5',9-anhydro-3-purine-isonucleosides as potential anti-hepatitis C virus agents.

机译：5'，9-脱水-3-嘌呤-异核苷作为潜在的抗丙型肝炎病毒制剂的合成及生物活性。

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In order to study structure-activity relationships among the derivatives and congeners of 5',9-anhydro-3-(beta-D-ribofuranosyl)xanthine for anti-hepatitis C virus activity, a series of 5',9-anhydro-purine-isonucleosides with a substituent (s) at 6- or/and 8-position of the purine moiety were synthesized, and their anti-hepatitis C virus activity and cytotoxicity were evaluated and discussed.

机译：为了研究5'，9-脱水-3-（β-D-核呋喃糖基）黄嘌呤的衍生物和同类物对丙型肝炎病毒活性的构效关系，一系列5'，9-脱水嘌呤合成了在嘌呤部分的6或/和8位带有取代基的β-异核苷，并评估和讨论了它们的抗丙型肝炎病毒活性和细胞毒性。

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来源
《Nucleosides, nucleotides and nucleic acids》 |2007年第1期|共15页
作者
Chun BK; Wang P; Hassan A; Du J; Tharnish PM; Murakami E; Stuyver L; Otto MJ; Schinazi RF; Watanabe KA;
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正文语种 eng
中图分类细胞形态学;
关键词
Antiviral Agents; Hepacivirus; Purine Nucleosides; 抗病毒药; 嘌呤核苷类;

机译：Antiviral Agents;Hepacivirus;Purine Nucleosides;抗病毒药;嘌呤核苷类;

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机译：5'，9-脱水-3-嘌呤-异核苷作为潜在的抗丙型肝炎病毒制剂的合成及生物活性。
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8. Synthesis of Nucleoside Analogues with Potential Antiviral Activity against Negative Strand RNA Virus Targets. [R] . Walker, R. T. 1989

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Synthesis and biological activity of 5',9-anhydro-3-purine-isonucleosides as potential anti-hepatitis C virus agents.

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