SYNTHESIS, ANTI-HUMAN IMMUNODEFICIENCY VIRUS AND ANTI-HEPATITIS B VIRUS ACTIVITIES OF 1,3-OXASELENOLANE NUCLEOSIDES

摘要

1,3-Oxaselenolane nucleosides of the formula:(see formula I)wherein B is a purine or pyrimidine base, and R is hydrogen, acyl, a mono-, di-ortri-phosphate ester, a stabilized phosphate or an ether lipid, andpharmaceuticallyacceptable salts thereof, are useful for the treatment of HIV infection, HBVinfection or abnormal cellular proliferation in humans and other host animals.