Hypothalamic hamartomas (HHs) are developmental, non-neoplastic malformations involving the small hypothalamic area located between the infundibular stalk and the mamillary bodies [1]. A spectrum of clinical conditions can be envisaged: (A) early-onset of laughter epileptic seizures (gelastic seizures, GS) in previously normal children evolving toward catastrophic generalized epilepsy with cognitive regression and severe behavioral problems with or without precocious puberty; (B) GS evolving toward severe focal epilepsy with cognitive and behavioral disturbances of various severity; (C) late infancy onset GS evolving toward severe focal epilepsy with little or without associated cognitive and behavioral signs [1].
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