Synthesis and molecular structure of novel 2-(alkylthio)-4-chloro-N-(4,5-dihydro-5-oxo-lH-l,2,4-triazol-3-yl)-5-methylbenzene-sulfonamides with potential anticancer activity

摘要

A series of novel 4-chloro-N-(4,5-dihydro-5-oxo-1-R~2-1H-1,2,4-triazol-3-yl)-5-methyl-2-(R~1-methylthio)ben-zenesulfonamide derivatives have been synthesized as potential anticancer agents. The in vitro antitumor activity of some compounds was evaluated in the US National Cancer Institute (NCI) against the NCI-60 cell line panel. The most prominent compound showed remarkable activity against 13 human tumor cell lines representing lung, colon, CNS, melanoma, ovarian, renal, prostate, and breast at low micromolar GI_(50) level in the range of 1.9-3.0 礛.