Synthesis of a new series of biologically interesting 6'-chloro-l',l/dioxospiro[4H-benzo[d][l,3,7]oxadiazocine-4,3/(2/H)[l,4,2]benzodithiazine]-2,6(lH,5H)dione derivatives

摘要

A series of 6'-chlorol',l'-dioxospiro[4Hbenzo[d][l,3,7]oxadiazocine-4,3'(2'H)-[l,4,2]benzodithiazine]2,6(1H,5H)dione derivatives have been synthesized from isatoic anhydride and 3-(R~2-amino)-l,4,2-benzodithiazine 1,1-dioxides. Some synthetic limitations are discussed on the basis of quantum chemical calculations performed by use of the Hartree-Fock method.