Seizure aggravation with antiepileptic drugs in idiopathic generalized epilepsies.

摘要

Idiopathic generalized epilepsies (IGE) are a group of genetically determined epilepsies and affect otherwise normal people and manifest with typical absences, myoclonic jerks, and generalized tonic-clonic seizures, either alone or in varying combinations and severity. Aggravation of seizures in IGE syndromes by antiepileptic drugs (AEDs) is increasingly recognized as a serious and common problem.Seizure aggravation is considered to be a paradoxical reaction when an AED increases the frequency and/or changes the pattern of a seizure type against which it is usually effective, or when it leads to the onset of new types of seizures.This usually occurs in the usual doses and normal serum levels and in the absence of any other clinical features suggestive of an encephalopathy or sedation.Clinical improvement occurs after dose reduction.