Acute kidney injury: Timing of biomarker increases in acute kidney injury.

摘要

A study reported in the Journal of the American College of Cardiology has shown the timing of elevation of predictive biomarkers in acute kidney injury (AKI).As an increase in serum creatinine level is a delayed marker of AKI in the acute setting, numerous studies have investigated various potential early biomarkers of AKI to enable earlier intervention. Urinary levels of neutrophil gelatinase-associated lipocalin (NGAL), interleukin (IL)-18, liver fatty acid binding protein (L-FABP) and kidney injury molecule (KIM)-1 have all been shown to be increased early after AKI, but most studies have only investigated these biomarkers individually.Krawczeski and colleagues set out to investigate the timing of elevation of each of these biomarkers in children who developed AKI following cardiac surgery. The researchers analyzed data from 220 patients aged <18 years who had undergone cardiac surgery with cardiopulmonary bypass (CPB).