Glomerular disease: MicroRNA-193a - A new pathogenic player and target in focal segmental glomerulosclerosis

摘要

Dysregulation of a single microRNA, miR-193a, induces a molecular cascade that leads to glomerular damage and focal segmental glomerulosclerosis (FSGS) in mice and humans, according to new research published in Nature Medicine. "These findings are novel because until now there has been no mechanistic insight into the pathogenesis of the majority of cases of FSGS," says researcher Dontscho Kerjaschki. "Genetic defects in certain constituent proteins, the circulating nephritogenic factor suPAR, and other known factors, together account for less than 50% of FSGS cases."