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Technology insight: microarrays--research and clinical applications.

机译:技术洞察力:微阵列-研究和临床应用。

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For microarrays, the transition from research to clinical and diagnostic applications is well underway. Microarrays use a range of specific probes that are immobilized in known locations on a support matrix; this technique can measure levels of specific DNA, RNA and proteins, as well as carbohydrates and lipids. It is anticipated that analysis of these levels will lead to identification of biomarkers for the diagnosis, treatment and prognosis of a wide range of diseases. So far, this type of analysis has been particularly useful in clinical oncology, but the technology is being actively and successfully explored for diseases such as diabetes, endocrine tumors and endocrine modulators of tumors. There are now many commercial sources of microarrays, which have robust quality-control procedures in place. Progress will be enhanced when biomarkers can be established, statistical approaches can be refined and when we better understand the interactions of genes and of particular gene loci in disease progression.
机译:对于微阵列,从研究到临床和诊断应用的过渡正在进行中。微阵列使用固定在支持基质上已知位置的一系列特异性探针。这项技术可以测量特定DNA,RNA和蛋白质以及碳水化合物和脂质的水平。预期对这些水平的分析将导致鉴定用于广泛疾病的诊断,治疗和预后的生物标志物。到目前为止,这种类型的分析在临床肿瘤学中特别有用,但是正在积极而成功地探索该技术以治疗糖尿病,内分泌肿瘤和肿瘤内分泌调节剂等疾病。现在有许多商业上的微阵列来源,它们都具有完善的质量控制程序。建立生物标志物,完善统计方法以及更好地了解疾病进程中基因和特定基因座的相互作用时,进展将会得到加强。

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