Ulcerative colitis: Intestinal microbiota manipulation is effective in children with ulcerative colitis.

摘要

Rectal infusion of Lactobacillus reuteri ATCC 55730 could be a new therapy for children with active distal ulcerative colitis, according to work by Oliva and colleagues. 40 children with mild-to-moderate ulcerative colitis were randomly assigned to receive either a rectal enema containing L reuteri ATCC 55730 or placebo for 8 weeks, in addition to oral mesalazine. In the 31 children who completed the study, mucosal inflammation and levels of proinflammatory cytokines (IL-1(3 and TNF) were decreased in those who received the lactobacillus rectal enema.