Fearful Symmetry: Subversion of Asymmetric Division in Cancer Development and Progression

摘要

Asymmetric division is an c-volulionarily conserved process that generates daughter tells with different fates through the unequal partitioning of fate determinants. While asymmetric division is critically important in generating diversity during development, its dysregulation can also promote oncogenesis. In particular, signals that shift the normal balance oi symmetric and asymmetric division can lead to a differentiation arrest and nigger cancer progression. Here, we discuss the studies that have proided increasing support for this idea. Beginning with original work carried out in Dmsophita, we trace more recent work in mammalian systems that suggest that the subversion of asymmetric-division ran contribute significantly to the development and progression of both hematologic malignancies and .solid cancers.