双相障碍和精神分裂症患者的大脑不对称性比较

摘要

Objective To explore the differences of krain laterality ketween kipolar disorder( BP)and schizophrenia( SZ). Methods According to the Diagnostic and Statistical Manual of Mental Disorders Fourth edition( DSM-IV)of American Psychiatric Association( APA),31 patients with BP,29 patients with SZ and 32 healthy controls( HC)were recruited in Guangzhou Huiai Hospi=tal from Decemker 2012 to Octoker 2014. MRI scan were used to all sukjects and laterality index(LI)were compared using FreeSurf=er. Results ①There were significant differences in the LI of superior temporal gyrus among groups(F=18. 425,P﹤0. 001). After LSD test,the LI of BP was largest,and the LI of SZ was smallest. ②There were significant differences in the LI of cortical thicdness among gourps(F=9. 251,P﹤0. 001). After LSD test,the LI ketween BP and SZ and the LI ketween SZ and HC were significant dif=ferent. There were no significant differences among groups in cortcal surface(F=0. 446,P=0. 642). Conclusion There were ak=normal laterality of krain volum in SZ and BP,which mayke lie in the cortical thicdness.%目的探讨双相障碍（ BP）和精神分裂症（ SZ）患者的大脑结构偏侧化差异。方法纳入2012年12月-2014年10月在广州市惠爱医院门诊及住院部就诊的、符合美国精神病学会（ APA）《精神障碍诊断与统计手册（第4版）》（ DSM-IV）诊断标准的双相障碍患者31例和精神分裂症患者29例，选取正常对照（ HC）32名。采用MRI扫描受试者大脑，使用FreeSurfer软件计算并比较各脑区的偏侧化指数（ LI）。结果①颞上回的LI，总体差异有统计学意义（ F=18.425，P﹤0.001）。两两比较，经LSD检验，BP最大，HC次之，SZ最小，差异均有统计学意义。②提取颞上回的平均皮层厚度和表面积，平均皮层厚度的LI，总体差异有统计学意义（ F=9.251，P﹤0.001）。两两比较，经LSD检验，BP和SZ、SZ和HC差异有统计学意义。表面积的LI，总体差异无统计学意义（ F=0.446，P=0.642）。结论 SZ和BP的大脑灰质体积偏侧化存在异常，这种异常可能主要受到平均皮层厚度的影响。