Homology modelling in protein structure prediction: Epidermal growth factor receptor kinase domain

摘要

The importance of homology modelling in predicting the three dimensional structures of proteins has been discussed. Efforts in improving the predictive quality are outlined. Successful implementation of homology modelling has been demonstrated in predicting the structure of the kinase domain of Epidermal Growth Factor Receptor (EGFR). A comparison between the modelled and experimental X-ray crystal structure (C-alpha RMSD 1.96 Angstrom) shows the accuracy of the modelling methods used.