Effect of Acanthopanads cortex Water Extract on Antioxidative Activity, Lipid Profile and Epidermal Thickness in DNCB-induced Allergic Contact Dermatitis Animal Model

摘要

The effects of Acanthopanads cortex water extract on allergic contact dermatitis (ACD) in Sprague-Dawley male rats treated with 2.5% l-chloro-2,4-dinitrochlorobenzene (DNCB) on the dorsal skin were evaluated. The concentration of TEARS in plasma and liver was increased in ACD rats and was significantly decreased in Acanthopanads cortex fed group (ACFG) compared to CG (control group). Serum Ig E level was significantly increased in CG compared to normal group, while that of ACFG was significantly decreased. The epidermal thickness of CG was significantly increased compared to that of normal group, while that of ACFG was significantly decreased compared to that of CG. These results indicated that the Acanthopanads cortex water extract administration improved lipid preoxidation, antioxidative activity, serum Ig E level and epidermal thickness in rats with ACD.