...
首页> 外文期刊>Mucosal immunology >Unique lamina propria stromal cells imprint the functional phenotype of mucosal dendritic cells
【24h】

Unique lamina propria stromal cells imprint the functional phenotype of mucosal dendritic cells

机译:独特的固有层基质细胞印记粘膜树突状细胞的功能表型

获取原文
获取原文并翻译 | 示例

摘要

Mucosal dendritic cells (DCs) in the intestine acquire the unique capacity to produce retinoic acid (RA), a vitamin A metabolite that induces gut tropism and regulates the functional differentiation of the T cells they prime. Here, we identified a stromal cell (SC) population in the intestinal lamina propria (LP), which is capable of inducing RA production in DCs in a RA-and granulocyte-macrophage colony-stimulating factor (GM-CSF)-dependent fashion. Unlike DCs, LP SCs constitutively expressed the enzymatic machinery to produce RA even in the absence of dietary vitamin A, but were not able to do so in germ-free mice implying regulation by microbiota. Interestingly, DCs promoted GM-CSF production by the SCs indicating a two-way cross-talk between both cell types. Furthermore, RA-producing LP SCs and intestinal DCs localized closely in vivo suggesting that the interactions between both cell types might have an important role in the functional education of migratory DCs and therefore in the regulation of immune responses toward oral and commensal antigens.
机译:肠道中的粘膜树突状细胞(DC)具有产生视黄酸(RA)的独特能力,视黄酸是一种维生素A代谢物,可诱导肠道嗜性并调节它们引发的T细胞的功能分化。在这里,我们在肠道固有层(LP)中鉴定了一个基质细胞(SC)群体,它能够以DC依赖RA和粒细胞巨噬细胞集落刺激因子(GM-CSF)的方式诱导DC中的RA产生。与DC不同,LP SC甚至在不存在饮食维生素A的情况下也组成性地表达酶机制来产生RA,但是在无菌小鼠中却不能这样做,这暗示着微生物群的调控。有趣的是,DC通过SC促进了GM-CSF的产生,表明两种细胞类型之间存在双向串扰。此外,产生RA的LP SC和肠道DC紧密定位在体内,这表明两种细胞类型之间的相互作用可能在迁移DC的功能教育中发挥重要作用,因此在调节针对口服和共生抗原的免疫反应中也起着重要作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号