Relationship between elevated lipid peroxides, vitamin E deficiency and hypertension in preeclampsia

摘要

Preeclampsia or pregnancy-induced hypertension is a major cause of both maternal and fetal-neonatal morbidity and mortal-ity. The deficiency of vitamin E can cause accumulation of lipid peroxidation products, which, in turn, can induce vasocon-striction. This study has examined any evidence of increased cellular lipid peroxidation and accumulation of malonydialdehyde (MDA, an end product of lipid peroxidation) in pregnancy-induced hypertension and any relationship between the elevated MDA and lower vitamin E levels with hypertension in pregnant women. EDTA-Blood was collected from pregnant women at the time of delivery. Plasma vitamin E was determined by HPLC; MDA by the thiobarbituric acid-reactivity. Subjects with diastolic blood pressure(DBP) > 90 mm Hg were considered hypertensive (HT) and with < 90 mm Hg normotensive (NT). Data (Mean ± SE) from 49 NT and 11 HT women show that HT has significantly lower vitamin E (22 ± 1 vs 27 ± 1 nmole/ml, p < 0.03) and elevated MDA levels (0.56 ± 0.06 vs 0.43 ± 0.02 nmole/ml, p < 0.03) compared to NT; the ages and gestational ages of women were similar. Among all women, there was a significant positive relationship between DBP and MDA levels (r = 0.27, p < 0.05), and a significant negative relationship between vitamin E levels and DBP (-0.36, p < 0.005), and a signifi-cant negative relationship between MDA and vitamin E levels (r = -0.27, p < 0.05). Thus, HT women's plasma has signifi-cantly lower E and higher MDA levels, and DBP significantly correlates with the extent of vitamin E deficiency and increased MDA levels. This study suggests a relationship between elevated lipid peroxidation and lower vitamin E levels and hyperten-sion in pregnancy (preeclampsia).