Magnetic SBA-15/poly(N-isopropylacrylamide) composite: Preparation, characterization and temperature-responsive drug release property

摘要

A novel magnetic targeting and temperature-responsive drug delivery system based on poly(N-isopropyl-acrylamide) (PNIPAM) modified mesoporous SBA-15 containing magnetic γ-Fe2O3 nanoparticles has been successfully prepared. The structure and morphology of the magnetic SBA-15/PNIPAM composite was characterized by X-ray diffraction, scanning electron microscopy (SEM), transmission electron microscopy (TEM), Differential scanning calorimetry (DSC) and N2 adsorption-desorption technique. This composite shows superparamagnetic behavior with the magnetization strength of 2.1 A m~2 kg~(-1) at 377 A m~(-1). Using gentamicin as a model drug, in vitro testing of gentamicin release exhibits a temperature-responsive controlled release property. Therefore, this magnetic SBA-15/PNIPAM composite could be applied in targeting and stimuli-responsive drug delivery.