磁性聚N-异丙基丙烯酰胺-聚丙烯酸纳米复合微球的制备与性能研究

摘要

In this study, a convenient approach has been proposed for the preparation of magnetic poly ( N-isopropylacrylamide)-poly (acrylic acid) (PNIPAm-PAA) hybrid nanospheres. In the first step, hollow PNIPAm-PAA nanocapules, of which the diameter was about 500 nm, were synthesized by precipitation polymerization with hydropropylcellulose-poly ( acrylic acid ) ( HPC-PAA) particles as the template. In the second step, the electrostatic interaction self-assembly method and the in situ reduction method were adopted to generate the magnetic Fe3O4 nanoparticles inside the nanocpsules. Thus the magnetic Fe3O4/PNIPAm-PAA hybrid nanospheres were finally obtained and the average diameter was 400 nm. In addition, a high drug loading capacity and a sustained-release behavior were presented by using anti-cancer drug Doxorubicin hydrochloride ( Dox ) as a hydrophilic model drug. It indicated that the Fe3O4/PNIPAm-PAA hybrid nanospheres might be used as a new magnetic-targeted drug carrier for the drug delivery system.%以天然高分子羟丙基纤维素-聚丙烯酸( HPC-PAA)胶体微粒为模板,通过沉淀聚合法获得中空结构的聚N-异丙基丙烯酰胺-聚丙烯酸( PNIPAm-PAA)纳米胶囊,平均粒径约为500 nm；然后运用静电作用自组装法和原位还原法将 Fe3O4磁性纳米粒子负载于 PNIPAm-PAA 纳米胶囊上,制备获得 Fe3O4/PNIPAm-PAA磁性纳米复合微球,粒径约为400 nm。制得的复合微球不仅具有一定的铁磁性(饱和磁化强度为5.5( A·m2)/kg,而且对抗肿瘤药物---盐酸阿霉素( Dox)显示了较高的载药率和较好的体外缓释效果,有望成为一种新型的靶向药物载体应用于药物输送体系。